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O3‐03‐04: Characteristics of the neighborhood built environment are associated with MRI brain volumetric and amyloid beta burden measures: Findings from the australian imaging, biomarkers, and lifestyle (AIBL) study
Author(s) -
Cerin Ester,
Ames David,
Ellis Kathryn A.,
Lautenschlager Nicola T.,
Rowe Christopher C.,
Rainey-Smith Stephanie R.,
Villemagne Victor L.,
Fowler Christopher,
Robertson Joanne S.,
Maruff Paul,
Macaulay S. Lance,
Martins Ralph N.,
Masters Colin L.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.251
Subject(s) - brain size , medicine , apolipoprotein e , neuroimaging , magnetic resonance imaging , psychology , disease , psychiatry , radiology
predominatlyChinese ethnicity inmild-moderateAD.The four-factor ZBI comprised role strain (demands), role strain (control), personal strain and worry about performance (WaP). PPR was defined by the upper pentile of Clinical Dementia Rating-Sum of Boxes (CDR-SB) score divided by duration of symptoms at presentation to yield 81 non-rapid and 20 rapid pre-progressors. We performed linear regression to determine the influenceof PPRon baseline ZBI total and factor scores, adjusted for Chinese Mini-Mental State Examination (CMMSE), instrumental activities of daily living (IADL), and Neuropsychiatric Inventory Questionnaire (NPI) scores. We then compared the 12-month ZBI total and factor scores between rapid and non-rapid pre-progressors.Results:At baseline, rapid pre-progressors had higher ZBI total (32.05617.17 vs 23.77613.55, p1⁄4.02), personal strain and WaP factor scores. Inmultivariate analysis, PPRwas no longer significantly associated with ZBI total and personal strain scores; the only significant predictor was NPI-severity. In contrast, for WaP, PPR remained significant in multivariate analysis; only CMMSE significantly predicted WaP. Ninety-four patients (93%) completed oneyear follow-up, comprising 74non-rapid and20 rapid pre-progressors. At 12-months, therewas no significant difference in total ZBI between rapid and non-rapid pre-progressors (29.85618.99 vs 26.19614.96, p1⁄4.36). Total ZBI paradoxically increased in non-rapid pre-progressors compared with a decline amongst rapid pre-progressors, driven mainly by a corresponding fall in WaP in the latter (P1⁄4.06). During this period, NPI scores remained relatively unchanged, whereas CMMSE, IADL andCDR-SB declined (P<.01).Conclusions:PPR exerts a differential temporal impact on caregiver burden and its specific dimensions. PPRmainly influences total ZBI at presentation,mediated via behaviour for personal strain and cognition forWaP. In contrast, the paradoxical relationship between PPR and 12-month ZBI is mainly attributable to decline in WaP with disease progression.