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O3‐02‐02: Trends in dementia incidence: Evolution over a 10‐year period in france
Author(s) -
Grasset Leslie,
Brayne Carol,
Joly Pierre,
Jacqmin-Gadda Hélène,
Peres Karine,
Foubert-Samier Alexandra,
Barberger-Gateau Pascale,
Dartigues Jean-François,
Helmer Catherine
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.243
Subject(s) - dementia , incidence (geometry) , population , demography , gerontology , medicine , vascular dementia , depression (economics) , cognitive decline , disease , environmental health , physics , sociology , optics , economics , macroeconomics
recovered in AD when specifically assessing the same brain areas (r1⁄40.42, p1⁄40.05; Figure 1A). Complementary analyses in MCI revealed i) increased metabolism related to higher years of education within these areas (Figure 1B) and ii) a positive relationship between education-related Ab increases and education-related increases in metabolism (r1⁄40.6, p1⁄40.001; Figure 1C). Conclusions:Our results may have different implications; first, considering normal older adults, MCI andAD, education-related compensation for Ab appears to be maximal at MCI stage. Second, higher metabolism in higher educated MCI patients may protect against the deleterious effects of Ab deposition such that more Ab deposition would be needed in higher educated MCI patients to convert to AD. Overall, we provide new insights into how CR may delay Ab effects on cognition.