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O2‐14‐05: Alpha‐synuclein oligomers acutely induce memory deficits and brain inflammation
Author(s) -
Forloni Gianluigi
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.212
Subject(s) - neuroinflammation , long term potentiation , neuroscience , tlr4 , memory impairment , dementia , synaptic plasticity , inflammation , microglia , alpha synuclein , psychology , parkinson's disease , medicine , cognition , immunology , pathology , disease , receptor
CR1 pathway. This finding may therefore help explain why miniscule amounts of anti-Ab antibodies reaching the brain (but not the meninges) through Ab immunization nonetheless result in enhanced Ab clearance. Conclusions: Given the collective data, we suggest that erythrocyte/CR1-mediated clearance of Ab may: A) play a significant role in AD, B) underlie the association of CR1 polymorphisms with AD risk, and C) help account for the ability of Ab immunization to remove brain Ab.