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O2‐11‐02: Early adult patterns of physical activity and television watching and mid‐life cognitive function
Author(s) -
Hoang Tina D.,
Reis Jared,
Zhu Na,
Jacobs David R.,
Launer Lenore J.,
Whitmer Rachel A.,
Sidney Stephen,
Yaffe Kristine
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.190
Subject(s) - digit symbol substitution test , quartile , stroop effect , cognition , audiology , psychology , medicine , confidence interval , psychiatry , alternative medicine , pathology , placebo
Analyses were adjusted for demographics, baseline cognition, APOE-ε4 carrier status, and cardiovascular risk factors. Results: During 11.5 6 5.3 years of follow-up, 1,193 participants suffered from dementia. In all participants, incident stroke or TIAwas associated with a significantly higher risk of dementia, HR 1.45 (95% CI: 1.23,1.70). In analyses stratified on education, the highest risk for dementia following stroke or TIAwas observed in the low education group, HR 1.48 (95%CI: 1.20,1.83), followed by the intermediate, HR 1.38 (95%CI: 1.05,1.83). No increased risk of dementia was observed after a stroke or TIA in the high education group, HR 0.77 (95%CI:0.32,1.84). Conclusions: Incident stroke or TIA was associated with a higher risk of dementia in the low and intermediate education groups, but not in the high education group. Our results support the role of cognitive reserve in protection against dementia after TIA or stroke.