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O2‐10‐05: Retinal nerve fiber layer thickness in posterior cortical atrophy and the visual variant of Alzheimer's disease
Author(s) -
Pelak Victoria Susan,
Eastes Joel
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.187
Subject(s) - nerve fiber layer , atrophy , retinal , medicine , ophthalmology , glaucoma , pathology , optical coherence tomography , posterior cortical atrophy , neuroscience , pathological , disease , psychology , dementia
0.93). The whole hypothalamus was subsequently segmented manually into five different subunits (Figure 1). Shape differences were investigated using the SPHARM-PDM toolbox. Results: The bvFTD group showed a 17% reduction in hypothalamic volume compared with controls (p<0.005, Mann-Whitney U test): right, mean 398 (standard deviation 62) versus 477 (38) mm and left, 385 (53) versus 467 (39)mm, corrected for total intracranial volume. MAPT mutation carriers showed a trend for lower volumes on both sides compared with C9orf72 (12% difference). Specifically, in both shape and volumetric analyses, we found a strong evidence for the involvement of the dorsal tuberal hypothalamus in bvFTD patients, compared with controls (Figure 2). No significant correlations were found with the clinical scores.Conclusions:In summary, bvFTD patients showed lower hypothalamic volumes compared with controls: this reduction is localized to the subnuclei that regulate food intake, reward and perception of satiety. Moreover, different genetic mutations seem to have a differential impact on the hypothalamus.