Premium
O2‐09‐02: ApoE‐ɛ4 genotype by gender interactions in regional amyloid accumulation in the Alzheimer's disease continuum
Author(s) -
Tosun Duygu,
Insel Philip S.,
Weiner Michael W.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.178
Subject(s) - apolipoprotein e , neuropathology , genotype , medicine , alzheimer's disease neuroimaging initiative , psychology , alzheimer's disease , disease , endocrinology , pathology , oncology , biology , genetics , gene
Background: After advanced age, ApoE-ε4 genotype is the most important risk factor for developing AD. It has been reported that the effects of the ApoE-ε4 genotype are more pronounced in women than in men. Postmortem data indicates higher risk of both neurofibrillary tangle and amyloid plaque neuropathology in the earliest stages of AD in women, especially ApoE-ε4-carriers, than in men. Furthermore, recent reports suggest that ApoE-ε4xgender interaction is detectable in the preclinical period, suggesting the mechanisms that underlie this interaction may be central to AD pathogenesis. To date, however, this interaction between gender and APOE status has not been explored in vivo in AD continuum. In this study, we investigated the effect of ApoEε4 genotype and gender on amyloid plaque neuropathology measured by in vivo florbetapir-PET. Methods: The sample consisted of baseline data from 346 cognitively normal (CN), 296 early-MCI, 250 late-MCI, and 148 AD subjects from ADNI-GO/ 2 studies. Within each diagnostic group separately, mean florbetapir-SUVR levels of temporal, parietal, cingulate, and frontal regions were tested for differences between APOE genotype, gender, and the interaction between the two with age and florbetapir-SUVR from a composite reference region as covariates, using linear regression models with p 0.05. Results:There was a significant difference on age between ApoE-ε4 groups across all diagnostic groups, but we did not find a significant difference in years of education. The distribution of gender across the ApoE-ε4-carrier/non-carrier groups did differ. No interaction between ApoE-ε4 and gender was observed for any of these measures. Main effect of ApoE-ε4 was associated with a higher florbetapirSUVR at each region-of-interest in each diagnostic group (0.12