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O2‐01‐06: Measurement of cortical mean diffusivity detects early microstructural breakdown of the cerebral cortex in presymptomatic familial Alzheimer's disease
Author(s) -
Weston Philip S.J.,
Lehmann Manja,
Simpson Ivor,
Toussaint Nicolas,
Harper Lorna,
Ryan Natalie S.,
MacPherson Kirsty,
Woodward Felix,
Zhang Hui,
Schott Jonathan M.,
Ourselin Sebastien,
Rossor Martin N.,
Fox Nick C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.135
Subject(s) - precuneus , entorhinal cortex , white matter , cortex (anatomy) , supramarginal gyrus , cerebral cortex , posterior parietal cortex , temporal cortex , inferior parietal lobule , neurodegeneration , neuroscience , medicine , pathology , cardiology , psychology , disease , hippocampus , magnetic resonance imaging , radiology , cognition , functional magnetic resonance imaging
which became significantly different earliest in the precuneus (p1⁄40.038) and supramarginal gyrus (p1⁄40.045) at >8 years before predicted onset. Conclusions: The cortical “signature” for FAD is similar to that described for sporadic AD, but with more parietal and less anterior temporal involvement. Presymptomatic thinned cortex was identified four years pre-predicted onset, with significantly increased rates of change detectable eight years prior to predicted onset. This FAD cortical “signature” may have utility in presymptomatic trials.