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S2‐01‐03: Analytic challenges and potential solutions in cognitive decline and dementia research: The melodem initiative
Author(s) -
Dufouil Carole,
Glymour Maria M.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.101
Subject(s) - dementia , set (abstract data type) , consistency (knowledge bases) , cognitive decline , cognition , neuropsychology , psychology , biostatistics , management science , medicine , data science , disease , computer science , psychiatry , public health , engineering , artificial intelligence , nursing , pathology , programming language
not available. S2-01-02 METHODS TO ACCOUNT FOR ATTRITION DUE TO DEATH IN DEMENTIA COHORT STUDIES Eric Tchetgen, Harvard School of Public Health, Boston, MA, USA. Contact e-mail: etchetge@hsph.harvard.edu Abstract not available.not available. S2-01-03 ANALYTIC CHALLENGES AND POTENTIAL SOLUTIONS IN COGNITIVE DECLINE AND DEMENTIA RESEARCH: THE MELODEM INITIATIVE Carole Dufouil, Maria M. Glymour, Centre INSERM U897, Bordeaux, France; UC San Francisco, San Francisco, CA, USA. Background:Several methodological challenges arise in studies of the determinants of dementia risk and cognitive decline. Some challenges are common in many research areas; others are more pervasive in dementia research. Currently, researchers handle these challenges differently, making it difficult to directly compare studies and combine evidence. Modifiable sources of inconsistency include the absence of consensus and definitive standards for best analytic approaches; different disciplinary traditions in epidemiology, clinical research, biostatistics, neuropsychology, psychiatry, geriatrics and neurology; and software and technical barriers.Methods:TheMEthods in LOngitudinal research on DEMentia (MELODEM) initiative was formed in 2012 to address these difficulties and achievegreater consistency in the process of selecting and applying preferred analytic methods across research on dementia risk and cognitive aging. The goals of MELODEM include fostering methodological innovation to address these challenges as well as improving understanding of tools to address each challenge. Results:The initial MELODEM findings outline a list of methodological problems that should routinely be addressed in dementia research thatwill be presented.Weadvance this list as aworking set of guidelines for transparent reporting of methods and results and therefore the best chance of accelerating scientific progress in identifying determinants as well as validating biomarkers for earlier diagnosis of Alzheimer’s disease. We will also illustrate issues and solutions in the fivemajor challenges that have been identified as priorities: (1) Selection, i.e., handling selection stemming from study participation, attrition, andmortality; (2)Measurement, i.e., dealing with the quality of measurements of exposure and outcomes and how imperfect measurement quality affects analysis and interpretation of results; (3) Alternative time scale, i.e., specifying the time-scale and the shape of trajectories in longitudinal models; (4) Time-varying exposures and confounding, i.e., accounting for changes in explanatory variables; and (5) High-dimensional data, i.e., analyzing complex and multidimensional data such as neuroimaging, genomic information, or database linkages. Conclusions:The MELODEM guidelines complement STROBE and CONSORT guidelines but focuses on technical challenges specific to dementia-related research. We anticipate that MELODEM will provide a platform for continued discussion and innovation of methodological tools to strengthen dementia research. S2-01-04 METHODOLOGICAL CONSIDERATIONS FOR DEMENTIA IN 90+ INDIVIDUALS Maria M. Corrada, University of California, Irvine, Irvine, CA, USA. Contact e-mail: mcorrada@uci.edu Abstract not available.not available. MONDAY, JULY 20, 2015 SYMPOSIA S2-02 THEBIOLOGYASSOCIATEDWITHGENETICABNORMALITIES