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O1‐12‐02: Retinal vascular imaging markers are associated with cognitive decline
Author(s) -
Cheung Carol Y.,
Ong Yiting,
Hilal Saima,
Ikram Mohammad Kamran,
Wong Tien Yin,
Chen Christopher
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.094
Subject(s) - cognitive decline , medicine , cardiology , retinal , dementia , cohort , odds ratio , confidence interval , ophthalmology , disease
magnitude in the parafoveal retinal nerve fiber layer (d1⁄40.61), inner nuclear layer (d1⁄40.68) and inner plexiform layer (d1⁄40.73) (Figure 1). Increased Ab burden was associated with worse visual perimetry performance (d1⁄40.55). Using blue-laser autofluorescence, we also identified the presence of more hypofluorescent drusen in Ab+ CN than AbCN participants (d1⁄41.59) (Figure 1).Conclusions:These results suggest that, in the preclinical stage of AD (i.e., Ab+ CN older adults), several of the retinal nerve cell layers show measurable increases in thickness – possibly reflecting inflammatory processes. We believe that this may precede eventual disease progression. This increase in thickness may also be a result of aggregation of drusen that may potentially contain Ab, which were typically observed to be present in several retinal cell layers, such as the ganglion cell and inner plexiform layers. This is in accord with recent findings where similar drusen were observed in the retinas of patients with MCI who underwent fundus autofluorescence using curcumin (Kayabashi, 2014).