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O1‐08‐04: Tract‐specific white matter hyperintensities disrupt the default mode network in Alzheimer's disease
Author(s) -
Taylor Alexander N.W.,
Kambeitz-Ilankovic Lana,
Gesierich Benno,
Simon-Vermot Lee,
Araque Caballero Miguel Ángel,
Müller Sophia,
Heshung Liu,
Ertle-Wagner Birgit,
Buerger Katharina,
Weiner Michael W.,
Dichgans Martin,
Duering Marco,
Ewers Michael
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.072
Subject(s) - default mode network , hyperintensity , dementia , white matter , neuroscience , atrophy , cognition , psychology , cardiology , medicine , disease , magnetic resonance imaging , radiology
predictors (except lesion size) and the same outcome. Analyses were also conducted by diagnostic group and by lobe. Results: In lesion-level models, lower CSF amyloid (i.e. higher cerebral amyloid) was associated with lower FA in all tissue types. In voxel-level analysis, lower CSF amyloid was associated with lower FA in bilateral periventricular occipital white matter (Fig. 1A). Lesion-level effects were present in subgroups with and without hypertension. Hypertension had its own independent effect on lower FA in lesion core and penumbra. Diagnostic group specific models suggested that these effects were driven by cognitively normal individuals, in whom amyloid associations with white matter FA extended into the corpus callosum and frontal lobe (Fig. 1B). Lobe specific models suggested that the lesion core and penumbra findings were due to amyloid-associated lesions in occipital and parietal white matter. Conclusions: Elderly individuals with elevated cerebral amyloid have poorer white matter integrity in all tissue types–WMH lesions, penumbra and healthy white matter—independent of hypertension history. The possibility that amyloid burden may independently contribute to widespread white matter degeneration independent of vascular risks should be further examined, especially in cognitively healthy elderly individuals.