Premium
O1‐08‐01: Distinctive cognitive trajectories related to amyloid and cerebrovascular disease in mild cognitive impairment patients
Author(s) -
Kim Hee Jin,
Yang Jin-Ju,
Kim Changsoo,
Kim Yeo Jin,
Lee Jong Min,
Jung Na Yeon,
Chin Juhee,
Cheo Yearn Seong,
Lee Kyung Han,
Kim Sung Tae,
Kim Jae Seoung,
Na Duk L.,
Seo Sang Won
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.069
Subject(s) - precuneus , cardiology , cognitive decline , atrophy , neuropsychology , pittsburgh compound b , medicine , cognition , psychology , effects of sleep deprivation on cognitive performance , white matter , longitudinal study , neuroscience , cognitive impairment , audiology , dementia , pathology , disease , radiology , magnetic resonance imaging
identified as hippocampal sparing, and 7/49 (14%) as limbic predominant variants. Hippocampal sparing subjects were significantly younger and trended worse on global cognitive measures and toward higher neocortical amyloid load (see Table). Conclusions:Differential patterns of tau pathology, consistent with neuropathological AD variants, were identified using [18F]-AV-1451 PET imaging. Further in vivo investigation and characterization of these AD subtypes in larger samples is warranted.