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O1‐04‐05: Hypertension, APOE‐ɛ4 allele, regional white‐matter hyperintensities, and cognitive decline in old age: A population‐based study
Author(s) -
Qiu Chengxuan,
Laveskog Anna,
Wang Rui,
Bronge Lena,
Wahlund Lars-Olof,
Bäckman Lars,
Fratiglioni Laura
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.049
Subject(s) - hyperintensity , cognitive decline , medicine , cardiology , dementia , apolipoprotein e , population , psychology , magnetic resonance imaging , disease , radiology , environmental health
Finally, EF (Crane et al. 2012), temporal lobe cortical thickness, and WMHI were compared between groups using a two-way ANCOVA (diagnosis by HTN/TX), covaried for age, gender, education, intracranial volume, scan type/field strength, and APOE ε4 status as appropriate. Results:In CN, SMC, and EMCI, participants treated with antihypertensives and those not treated but who show HTN at the visit generally show poorer EF, reduced temporal lobe thickness, and greater WMHI than those without HTN (Fig1). No such pattern was observed in LMCI and AD, except for high WMHI in uncontrolled, treated AD patients. Lower EF, temporal lobe thickness, and higher WMHI were observed in uncontrolled, treated EMCI relative to all other EMCI participants. Conclusions: HTN has a significant effect on EF, brain atrophy, andWMHI in CN, SMC, and EMCI. Antihypertensive treatment is an important mediating factor when evaluating the effect of HTN. Longitudinal studies assessing the effects of high BP, HTN history, and successful vs. unsuccessful antihypertensive treatment on dementia risk and brain changes are needed to fully understand the role of HTN in preclinical and prodromal stages of dementia. O1-04-05 HYPERTENSION, APOE34 ALLELE, REGIONAL WHITE-MATTER HYPERINTENSITIES, AND COGNITIVE DECLINE IN OLD AGE: A POPULATION-BASED STUDY Chengxuan Qiu, Anna Laveskog, Rui Wang, Lena Bronge, LarsOlof Wahlund, Lars B€ackman, Laura Fratiglioni, Karolinska Institutet, Stockholm, Sweden; Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden; AgingResearchCenter,Karolinska Institutet&Stockholm University, Stockholm, Sweden. Contact e-mail: chengxuan.qiu@ki.se