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O1‐04‐03: Untangling the relationship between mid‐life adiposity and late‐life dementia: A systematic review and meta‐analysis of longitudinal cohort and record linkage studies
Author(s) -
Egan Kieren J.,
Giannakopoulos Panteleimon,
Prince Martin J.,
Albanese Emiliano
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.047
Subject(s) - overweight , dementia , meta analysis , record linkage , medicine , body mass index , cohort study , population , prospective cohort study , confidence interval , obesity , demography , cohort , gerontology , relative risk , disease , environmental health , sociology
dementia. Compared to thosewithout T1D thosewith T1Dwere 83% more likely to get dementia (Hazard Ratio {HR} 1.83, 95% Confidence Interval {CI} 1.3,2.5) and 61% more likely after adjustment for stroke, PAD and hypertension. When excluding those with T2D from the reference group, the magnitude of T1D on dementia risk was larger (HR1⁄41.93, 95% CI,1.3,2.6; fully adjusted HR 1.73, 95% CI 1.3,2.3). Conclusions:This is the first study of dementia in elderly adults with T1D. Those with T1D were 80% more likely to get dementia than those without T1D. Since management of T1D requires vigilance and constant self-care; cognitive impairment poses a threat to this vulnerable population. Future studies need to identify risk and protective factors for dementia in this group newly entering the aging population.