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O1‐02‐01: Microglial‐derived proteins in CSF are candidate biomarkers for early diagnosis of Alzheimer's disease
Author(s) -
Pike Ian,
Russell Claire,
Heslegrave Amanda J.,
Mitra Vikram,
Pocock Jennifer,
Zetterberg Henrik,
Hardy John,
Ward Malcolm
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.033
Subject(s) - microglia , biomarker , neuroinflammation , proteomics , quantitative proteomics , chemistry , biology , microbiology and biotechnology , immunology , inflammation , biochemistry , gene
and insula) and in temporal lobe. Volume of WMHs was distinctive of dementia status in YO but not in OO. Conclusions:The emphasis on decline in medial temporal and posterior brain regions in the non-demented OO is different from the documented “fronto-temporal” pattern in young elders and the temporo-parietal pattern in typical Alzheimer’s disease. Absence of dementia in the OO correlates with relatively preserved anterior cortex and the temporal lobe, which could inform mechanisms of cognitive maintenance in late life.