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O1‐01‐06: Correlation between ASL and o‐15 water PET in the adult children study
Author(s) -
Friedrichsen Karl A.,
Benzinger Tammie L.S.,
Blazey Tyler,
Couture Lars,
Vlassenko Andrei,
Joseph-Mathurin Nelly,
Owen Christopher J.,
Hornbeck Russ C.,
Su Yi,
Ances Beau,
Morris John C.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.032
Subject(s) - cerebral blood flow , precuneus , correlation , medicine , nuclear medicine , cerebral perfusion pressure , pittsburgh compound b , cardiology , psychology , alzheimer's disease , disease , radiology , functional magnetic resonance imaging , geometry , mathematics
and insula) and in temporal lobe. Volume of WMHs was distinctive of dementia status in YO but not in OO. Conclusions:The emphasis on decline in medial temporal and posterior brain regions in the non-demented OO is different from the documented “fronto-temporal” pattern in young elders and the temporo-parietal pattern in typical Alzheimer’s disease. Absence of dementia in the OO correlates with relatively preserved anterior cortex and the temporal lobe, which could inform mechanisms of cognitive maintenance in late life.