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P3‐124: A depressive endophenotype for predicting cognitive decline among mexican american adults and elders
Author(s) -
Johnson Leigh Ann,
O'Bryant Sid,
Hall James,
Edwards Melissa,
Vintimilla Raul,
Guzman Adriana Gamboa,
Knebl Janice,
Moss Amy
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.992
Subject(s) - endophenotype , logical address , depression (economics) , depressive symptoms , psychology , cognition , cognitive decline , clinical psychology , disease , medicine , psychiatry , dementia , physical address , computer science , programming language , economics , macroeconomics , overlay
Background:Late life depression is both a prodromal feature of and risk factor for Alzheimer’s disease (AD); however, identification of those AD patients who suffer from depression-related cognitive dysfunction remains difficult. In previous work, we identified a clinically-defined depressive endophenotype (DepE) that was found to be related to poorer cognition as well as increase risk for MCI and AD across multiple independent cohorts. The goal of this study was to examine the ability of DepE on memory over time. Methods: Baseline and 12 month follow up data were analyzed from 300 participants of the Health and Aging Brain study. DepE scores were dichotomized into two groups (>1⁄42 or <2) and related to change in memory scores over time. Results: ANOVA of total scores revealed significant differences between groups on WMS III Logical Memory 1 (immediate memory) (p < 0.05) in women. No significant differences were found between groups on men or WMS III Logical Memory 2 (long term memory) in either gender. Conclusions:Elevated DepE scores were associated with a decline in immediate verbal memory among women, but not men over 12 months.