Premium
P3‐120: Separate functional neural correlates of memory deficits in amnestic mild cognitive impairment with high and low beta‐amyloid burden
Author(s) -
Seo Eun Hyun,
Kim Sang Hoon,
Park Sang Hag,
Kang Seong-Ho,
Choo I.L. Han
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.988
Subject(s) - statistical parametric mapping , neuroimaging , alzheimer's disease neuroimaging initiative , psychology , positron emission tomography , cognitive impairment , cognition , functional neuroimaging , audiology , neuroscience , medicine , magnetic resonance imaging , radiology
diagnostic groups (p<0.001) with theMCI group having a greater proportion of participants with low output and low AI (NC 21%, MCI 40%) and the NC group having a greater proportion of participants with high output and high AI (NC 41%, MCI 14%). When comparing MCI severity subtypes, both output (early 19+5, middle 17+5, late 11+5) and AI (early 3.3+0.5, middle 3.3+0.6, late 2.7+0.9) differed among subtypes (p<0.001). Conclusions: MCI participants demonstrate both a decrease in total output compared to NC participants as well as a decline in semantic relatedness. Combining output and AI may be predictive of MCI status relative to normal cognition.