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P3‐117: Nutrition and dementia project (NutrDem project)
Author(s) -
Magierski Radoslaw,
Magierska Joanna,
Kloszewska Iwona,
Sobow Tomasz
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.985
Subject(s) - clinical dementia rating , bioelectrical impedance analysis , geriatric depression scale , dementia , medicine , anthropometry , montreal cognitive assessment , depression (economics) , neuropsychology , malnutrition , physical therapy , gerontology , cognition , body mass index , psychiatry , cognitive impairment , depressive symptoms , economics , macroeconomics , disease
circuitry was assessed using BOLD fMRI two weeks earlier among 7 of the individuals with MCI and 6 age-, gender-, and educationmatched healthy controls. Results:We found that high level mental fatigability disrupted the normal U shape of HF-HRV reactivity to cognitive stress in individuals with MCI. Furthermore, the stronger connectivity of intra-network of central executive network and the inter-network between central executive network and basal ganglia network (especially between the bilateral middle prefrontal cortex and left putamen) within the frontal basal ganglia circuitry (Figure 1) were related to lower mental fatigability and stronger HF-HRV reactivity in both MCI and healthy control (Figure 2). Conclusions: These results indicate that mental fatigability may contribute to abnormal cardiovascular reactivity to acute stress in MCI, and frontal basal ganglia circuitry may support such a link.