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P3‐116: Neuropsychiatric symptoms of mild cognitive impairment as a risk factor of progression to dementia
Author(s) -
Ryu Seung-Ho
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.984
Subject(s) - dementia , disinhibition , depression (economics) , risk factor , medicine , psychiatry , logistic regression , psychology , clinical psychology , disease , economics , macroeconomics
circuitry was assessed using BOLD fMRI two weeks earlier among 7 of the individuals with MCI and 6 age-, gender-, and educationmatched healthy controls. Results:We found that high level mental fatigability disrupted the normal U shape of HF-HRV reactivity to cognitive stress in individuals with MCI. Furthermore, the stronger connectivity of intra-network of central executive network and the inter-network between central executive network and basal ganglia network (especially between the bilateral middle prefrontal cortex and left putamen) within the frontal basal ganglia circuitry (Figure 1) were related to lower mental fatigability and stronger HF-HRV reactivity in both MCI and healthy control (Figure 2). Conclusions: These results indicate that mental fatigability may contribute to abnormal cardiovascular reactivity to acute stress in MCI, and frontal basal ganglia circuitry may support such a link.