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P3‐097: Serum interleukin 1 alpha and alpha 2 macroglobulin levels in patients with early‐ or late‐onset Alzheimer's disease or mild cognitive impairment
Author(s) -
Atasoy Irem L.,
Dursun Erdinc,
Gezen-Ak Duygu,
Hanağası Haşmet,
Bilgiç Başar,
Lohmann Ebba,
Ertan Sibel,
Alaylıoğlu Merve,
Araz Ömür S.,
Önal Burak,
Gündüz Ayşegül,
Kızıltan Güneş,
Apaydın Hülya,
Ulutin Turgut,
Gurvit Hakan I.,
Yılmazer Selma
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.964
Subject(s) - dementia , medicine , alpha 2 macroglobulin , cognitive impairment , disease , pathogenesis , endocrinology , gastroenterology , macroglobulin
aim of the current study was to compare levels of trace element Cu (free copper and ceruloplasmin bound) in the serum of AD patients (n1⁄444) and matched controls (n1⁄452). The objectives also included assessing their relationship with cognitive and behavioural and psychological functioning associated with dementia. Tools used were Clinical Dementia Rating (CDR), Hindi Mental Status Examination (HMSE), Everyday Abilities scale for Indians (EASI) and Neuropsychiatric Inventory (NPI) Results: Gender distribution among AD group was 45% males and 55% females and in HC group 52% males and 48% females. Mean age at assessment for AD group was 68.32 69.74 years and for HC group was 65.75 67.6 years. No significant difference was found between the two groups on age and gender. AD group obtained a lower mean score as compared to the HC group on HMSE, and higher on CDR, EASI & NPI indicating a poorer performance by AD group. AD group was found to have lower levels of total serum copper level (102.2 6 23.6 ug/dl) as compared to the control group (115.9627.9 ug/dl). Also, Serum free copper level was found to be lower in AD group (34.1611.2 ug/dl) as compared to HC group (46.1614.8 ug/dl). No significant difference was found between the two groups on Serum ceruloplasmin levels Both total and free copper (but not ceruloplasmin per se) were found to be lesser (p1⁄40.01 and p<0.001 respectively) in cases than in controls. Conclusions:No appreciable difference could be noted in levels of serum ceruloplasmin between the AD and healthy control groups. However, significant decrease observedwith copper levels in the AD may account, in part, for decreased copper-dependent biochemical activities such as cytochrome c oxidase required for energy generation and superoxide dismutase (free radical scavenging enzyme) described in AD.