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P3‐092: Plasma and cerebrospinal fluid amyloid‐b levels in late‐life depression: A systematic review and meta‐analysis
Author(s) -
Fiaux do Nascimento Kenia Kelly,
Pereira Kelly Silva,
SatlerS. Diniz Breno,
Malloy-Diniz Leandro F.,
Butters Meryl
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.959
Subject(s) - meta analysis , depression (economics) , late life depression , cerebrospinal fluid , medicine , web of science , scopus , strictly standardized mean difference , quality of life (healthcare) , plasma levels , medline , biology , biochemistry , nursing , hippocampal formation , economics , macroeconomics
appropriate therapy and prevention. We determined the possible role of oxidative stress in the pathophysiology of diabetes-related dementia. Methods:We classified 175 patients with clinically diagnosed Alzheimer disease (AD) and DM into 4 subgroups based on brain imaging in a 2013 study (Dement Geriatr Cogn Disord). Among them, we measured endogenous plasma antioxidants, such as albumin, unconjugated bilirubin, and uric acid, and urinary 8-hydroxy-20-deoxyguanosine (8-OHdG) and 8-epiPGF2a (8-isoprostane) in 58 patients of an AD group showing decreased regional cerebral blood flow (rCBF) of the parietotemporal lobe on single photon emission CT (SPECT) (AD+DM group) and 35 patients of a diabetes-related dementia (DrD) group showing neither decreased rCBF of the parietotemporal lobe nor cerebrovascular disease, which is strongly associated with DM-related factors. Thirty-one patients with AD and without DM (AD DM group) were enrolled as a control group. Results:The DrD group showed a significant decrease in plasma levels of antioxidants and a significant increase in urinary 8-OHdG and 8-isoprostane levels in contrast to the AD DM or AD+DM groups. Cognitive performance was negatively correlated with urinary 8-OHdG and 8-isoprostane levels in the DrD group. Conclusions: These results strongly suggest that a decrease in antioxidant levels and an increase in oxidative damage may be involved in the pathophysiology and cognitive decline associated with DrD. Intervention for oxidative stress could be considered an appropriate therapy and prevention of DrD.