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P3‐085: Interaction network of tau protein, beta‐amyloid protein, and amyloid protein precursor under oxidative stress in Alzheimer's disease
Author(s) -
SouzaS. Nicolau Eduardo,
Mendes Silva Ana Paula,
Fiaux do Nascimento Kenia Kelly,
Pereira Kelly Silva,
Ribeiro dos Santos Gizele,
Silva Barroso Lucélia,
Satler Diniz Breno
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.952
Subject(s) - amyloid precursor protein , oxidative stress , microrna , amyloid beta , amyloid (mycology) , gene , biology , alzheimer's disease , gene silencing , bioinformatics , disease , computational biology , genetics , medicine , biochemistry , botany
analyzed the correlation of plasma MIF levels with spatial learning and memory impairment in the AD mouse model. Results:ELISA analysis also showed that plasma MIF levels were significantly elevated at an early age of 2 months old and the elevation was in an age-dependent manner. The statistical analysis revealed highly negative correlations of plasma MIF levels with spatial learning and memory abilities as assessed by both Morris water maze test and step-down test. Conclusions: Our data demonstrated that increased levels of MIF in plasma occurred at a very early stage in the AD mouse model, and the high correlation of plasma MIF levels with cognitive impairment, suggesting that the change of MIF in plasma could serve as an early biomarker for AD. Acknowledgements This work was supported by NSFC (the National Natural Science Foundation of China) (81102154, 21271131, 31470804), Medical Scientific Research Foundation of Guangdong Province (A2013598), Shenzhen Scheme of Science and Technology (Medicine and Health) (201302148), Shenzhen Special Fund Project on Strategic Emerging Industry Development (JCYJ20130329103949650, JCYJ20120616144140857) and the Upgrade Scheme of Shenzhen Municipal Key Laboratory (JCYJ20130408172946974).