Premium
P3‐083: Impact of vitamin B12 on memory performance, hippocampus structure, and function in patients with mild cognitive impairment
Author(s) -
Köbe Theresa,
Witte Veronica A.,
Schnelle Ariane,
Grittner Ulrike,
Tesky Valentina,
Pantel Johannes,
Schuchardt Jan Philipp,
Hahn Andreas,
Bohlken Jens,
Rujescu Dan,
Flöel Agnes
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.950
Subject(s) - vitamin b12 , medicine , hippocampus , memory impairment , cognition , homocysteine , vitamin , audiology , verbal memory , endocrinology , psychiatry
(early-or late-onset; n:21, n:53,respectively), MCI (n:30) and PD (n:40) in this study to investigate the effect of vitamin D on the serum levels of IL-1b, IL-6, TNFa and BDNF, to see the vitamin D regulation of inflammatory response and neurotrophin synthesis in neurodegenerative disorders with different molecular backgrounds. Results:Our results indicated that the serum 25OHD levels of EOAD, LOAD and PD patients were significantly lower than their age-matched controls or MCI patients (p<0.05). Serum 25OHD levels and MMSE scores showed a significant correlation in healthy controls, EOAD and MCI patients. In addition lower 25OHD levels were correlated with younger age or younger age of onset in EOAD patients. Although 25OHD levels were inversely correlated with serum TNFa, IL-1b, IL-6 levels in healthy controls andMCI patients, 25OHDwere positively correlated with same cytokines in LOAD patients. Serum 25OHD levels were not correlated with age, age of onset, MMSE scores, UPDRS-ADL, Schwab-England-ADL scale and LEDD of PD patients. 25OHD were not correlated with IL-1b or IL-6 in that group. Finally, BDNF level was correlated with serum 25OHD only in healthy controls. Conclusions:Our results demonstrate that patients with neurodegenerative disorders have quite low levels of vitamin D in Turkish population. Given the results of three independent groups of individuals (healthy control, MCI, EOAD), vitamin D may regulate three important and related cytokines TNFa, IL-1b, IL-6. The power of vitamin D on regulation of systemic immune response and BDNF are compromised in EOAD, LOAD and PD due to low levels of vitamin D but not entirely in MCI.