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P3‐061: Last and art aphasia screening tools: Switching context from stroke to neurodegenerative diseases
Author(s) -
Saade Yasmina Michel,
Arbizu Céline,
Ferrieux Sophie,
Saratxaga Adriana Amaya,
Roze Constance Flamand,
Flamand-Roze Emmanuel,
Azuar Carole,
Dubois Bruno,
Teichmann Marc,
Epelbaum Stéphane
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.928
Subject(s) - aphasia , context (archaeology) , primary progressive aphasia , stroke (engine) , medicine , medical diagnosis , audiology , boston naming test , disease , psychology , dementia , psychiatry , pathology , frontotemporal dementia , engineering , biology , paleontology , mechanical engineering
correlated with AAO in the PCA patients. Results:Early onset PCA was associated with lower cortical thickness bilaterally in the inferior parietal lobe, angular gyrus and precuneus, whilst late onset PCAwas associated with lower thickness in frontal and medial temporal lobe regions (Figure 1). Consistent with the imaging findings, early onset PCA was associated with worse performance on digit span (0.53, p 1⁄4 0.001), calculation (0.48, p 1⁄4 0.003) and spelling (0.29, p1⁄4 0.026) all of them tests associated with dominant parietal function. Conclusions: Our data suggest that early-onset PCA patients have a greater involvement of bilateral (especially dominant) posterior cortices, and question the factors driving the relationship between age at onset and phenotypic heterogeneity not just between but also within the recognised atypical AD phenotypes.