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P3‐059: The motifs within amyloid beta peptide in processes of oligomerization and neurotoxicity
Author(s) -
Jingming Shi,
Dongya Yuan
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.926
Subject(s) - neurotoxicity , amyloid beta , monoclonal antibody , thioflavin , peptide , chemistry , amyloid (mycology) , sequence (biology) , microbiology and biotechnology , antibody , biology , biochemistry , alzheimer's disease , medicine , pathology , disease , immunology , toxicity , inorganic chemistry , organic chemistry
(2480.126 1379.05 ng/L) was significantly lower than the control group (3070.346 1390.53 ng/L) (P<0.05);Han’s MCI group Klotho protein concentration (2810.35 6 1417.74 ng/L) was significantly lower than the Han’s control group (3341.87 6 1375.47 ng/L) (P<0.05); Uygur’s MCI group Klotho protein concentration (2215.376 1297.67 ng/L) was significantly lower than the Uygur’s control group (2840.36 6 1361.65ng / L) (P<0.05); (2) Uygur’s MCI group Klotho protein concentration was significantly lower than the Han’s MCI group (P<0.05); Uygur’s control group Klotho protein concentration was also significantly lower than the Han’s control group (P <0.05). (3) Klotho protein concentration correlated with MMSE scores (rs1⁄4 0.209, P<0.05), and also correlated with age (rs1⁄4 -0.240, P<0.05). Conclusions:(1) We suspected that Klotho protein would associate with MCI and reduced Klotho protein concentration would promote the development of MCI. (2) Klotho protein concentration is lower in Uygur, so it would differ among different ethnic. (3) The content of Klotho protein of body could be gradually reduced with increasing age.