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P3‐044: Testosterone deprivation accelerates cognitive impairment in obese insulin‐resistant rats
Author(s) -
Chattipakorn Siriporn C.,
Pintana Hiranya,
Pratchayasakul Wasana,
Sa-nguanmoo Piangkwan,
Pongkan Wanpitak,
Tawinvisan Rungroj,
Chattipakorn Nipon
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.910
Subject(s) - synaptic plasticity , insulin resistance , endocrinology , long term potentiation , hippocampal formation , medicine , dendritic spine , morris water navigation task , testosterone (patch) , hippocampus , insulin , psychology , receptor
during spatial learning on the Morris water maze (MWM). Two weeks after their initial exposure to the MWM, mice were retested on the MWM in an altered spatial environment without exposure to CNO. Results: During the spatial learning portion of the MWM, APP/PS1 mice expressing hM3Dq (APP/PS1-hM3Dq) trended towards better performance on last day of testing when compared to APP/PS1 mice infused with the control AAV (APP/PS1-GFP). Twenty-four hours after the last learning trial, we tested spatial memory. APP/PS1 mice expressing hM3Dq performed significantly better than APP/PS1-GFP mice. Two weeks later, the APP/ PS1-hM3Dq group performed significantly better during both spatial learning and memory portions of the altered MWM when compared to the APP/PS1-GFP group. Conclusions: The direct facilitation of neuronal depolarization ameliorates cognitive deficits in the APP/PS1 mouse model of AD.