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P3‐011: Genome‐wide association of plasma homocysteine in the indianapolis‐ibadan dementia study cohort
Author(s) -
Kim Sungeun,
Lai Dongbing,
Lane Katie,
Ramanan Vijay K.,
Murrell Jill R.,
Gao Sujuan,
Hall Kathleen S.,
Foroud Tatiana M.,
Baiyewu Olusegun,
Ogunniyi Adesola,
Gureje Oye,
Hendrie Hugh C.,
Saykin Andrew J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.877
Subject(s) - genome wide association study , single nucleotide polymorphism , genetic association , imputation (statistics) , snp , homocysteine , heritability , dementia , medicine , cohort , genetics , oncology , bioinformatics , biology , genotype , gene , disease , statistics , mathematics , missing data
SNPs was related to AD and other neurological disorders. Further filtering for brain eQTL involvement identified 84 SNP candidates suitable for further investigation. A pathway enrichment analysis investigating SNP candidates related to AD is ongoing and we expect a wide distribution of involved biological pathways to quantify pathway specificity. Conclusions: The proposed annotation approach poses a promising filtering mechanism to investigate genetic variants associated with AD. Analyzing pathway specificity of these variants can be a powerful technique to prioritize novel biological targets.