Premium
P3‐010: Assessment of genetic overlap between serum iron levels and risk of Alzheimer's disease
Author(s) -
Lupton Michelle K.,
Benyamin Beben,
Wright Margie,
Powell John F.,
Nyholt Dale,
Ferreira Manuel,
Bush Ashley,
Heath Andrew,
Madden Pamela,
Martin Nick,
Montgomery Grant,
Whitfield John
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.876
Subject(s) - disease , confounding , genome wide association study , allele , alzheimer's disease , dementia , phenotype , genetic association , single nucleotide polymorphism , genetics , pathogenesis , biology , bioinformatics , medicine , gene , genotype
SNPs was related to AD and other neurological disorders. Further filtering for brain eQTL involvement identified 84 SNP candidates suitable for further investigation. A pathway enrichment analysis investigating SNP candidates related to AD is ongoing and we expect a wide distribution of involved biological pathways to quantify pathway specificity. Conclusions: The proposed annotation approach poses a promising filtering mechanism to investigate genetic variants associated with AD. Analyzing pathway specificity of these variants can be a powerful technique to prioritize novel biological targets.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom