Premium
P3‐010: Assessment of genetic overlap between serum iron levels and risk of Alzheimer's disease
Author(s) -
Lupton Michelle K.,
Benyamin Beben,
Wright Margie,
Powell John F.,
Nyholt Dale,
Ferreira Manuel,
Bush Ashley,
Heath Andrew,
Madden Pamela,
Martin Nick,
Montgomery Grant,
Whitfield John
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.876
Subject(s) - disease , genome wide association study , confounding , alzheimer's disease , allele , dementia , genetic association , phenotype , single nucleotide polymorphism , genetics , pathogenesis , biology , medicine , bioinformatics , gene , genotype
SNPs was related to AD and other neurological disorders. Further filtering for brain eQTL involvement identified 84 SNP candidates suitable for further investigation. A pathway enrichment analysis investigating SNP candidates related to AD is ongoing and we expect a wide distribution of involved biological pathways to quantify pathway specificity. Conclusions: The proposed annotation approach poses a promising filtering mechanism to investigate genetic variants associated with AD. Analyzing pathway specificity of these variants can be a powerful technique to prioritize novel biological targets.