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P3‐005: In vitro screen for inhibitors of tau filament formation
Author(s) -
Taub Nicole,
Kolb-Lenz Dagmar,
Hutter-Paier Birgit,
Schweinzer Cornelia
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.871
Subject(s) - microtubule , tau protein , chemistry , fluorescence , biophysics , biochemistry , in vitro , fibril , pathogenesis , microbiology and biotechnology , alzheimer's disease , biology , disease , pathology , medicine , immunology , physics , quantum mechanics
high predictive power for the discrimination of AD/healthy, MCIconv/MCIstable, MCIconv/healthy (Table 1). Conclusions: Our model provides a multimodal description of AD across clinical groups which is highly discriminative of disease staging. Results show that the pattern of atrophy/hypometabolism specific of prodromal AD is primarily localized in the subcortical temporal areas, and that it subsequently spreads to temporal, parietal and posterior cortices during the latest stages. Our approach provides a novel instrument for multimodal analysis of imaging data in AD, and can be further extended to multiple modalities and clinical groups to provide a multimodal, whole brain model of disease progression.