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P2‐323: Toll‐like receptor 9 stimulation via CpG ODN in a non‐human primate model of sporadic cerebral amyloid angiopathy
Author(s) -
Scholtzova Henrieta,
Nehete Pramod N.,
Nehete Bharti P.,
Mallory Melanie M.,
Cho Elizabeth,
Holmes Andrea,
Park Jina,
Wren Melinda S.,
Pardington Paige,
Gupta Goutam,
Mehta Pankaj D.,
Williams Lawrence E.,
Wisniewski Thomas
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.865
Subject(s) - tlr9 , marmoset , medicine , cerebral amyloid angiopathy , stimulation , primate , immunology , immune system , cpg oligodeoxynucleotide , nonhuman primate , biology , neuroscience , disease , dementia , paleontology , biochemistry , gene expression , gene , dna methylation , evolutionary biology
recapitulated the anti-oxidant metabolite profile. These cells have decreased intermediates of glycolysis and increased intermediates in the TCA cycle, increased glutathione and NAD levels, and increased levels of g-glutamyl dipeptides. Conclusions: The metabolome profile suggests RAGE deletion increases the anti-oxidant capacity of brain in APP mice. This data suggests RAGE deletion alters the CNS response to oxidative stress and inflammation, providing neuroprotection during disease progression.