Premium
P2‐299: Circadian rhythm alteration in dementia: Implications for non‐pharmacological therapies
Author(s) -
Zendehbad Azadeh,
Noroozian Maryam,
Mohammadi Maryam
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.840
Subject(s) - circadian rhythm , dementia , medicine , melatonin , dark therapy , population , effects of sleep deprivation on cognitive performance , cognition , psychiatry , disease , environmental health
selected from the memory clinic based Amsterdam Dementia Cohort of the VUmc Alzheimer Center. Results: Analyses of paired CSF, serum, and plasma samples of the Amsterdam Dementia Cohort are ongoing. Among others, levels of the following nutrients are being measured: plasma and CSF choline, uridine, and homocysteine, serum and CSF folate, and plasma polar lipid profile. The initial results show lower levels of CSF uridine and CSF folate and higher levels of CSF choline and CSF and plasma homocysteine in AD patients compared to the subjective memory complaints control group. Decremental and incremental changes ranged from 5 to 20% of the control group. Conclusions: The current study may further elucidate the role of these nutrients in AD pathology by identifying their levels in plasma and CSF at different stages of the disease. Furthermore, these nutrients may potentially serve as modifiable risk markers for AD.