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P2‐263: State and trait‐dependent associations of vitamin d with brain function and structure during aging
Author(s) -
Kueider Alexandra M.,
Thambisetty Madhav,
Elango Palchamy,
Davatzikos Christos,
Guray Erus,
An Yang,
Tanaka Toshiko,
Kitner-Triolo Melissa,
Ferrucci Luigi
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.804
Subject(s) - single nucleotide polymorphism , confounding , minor allele frequency , dementia , snp , vitamin d and neurology , medicine , cognitive decline , oncology , genetics , biology , disease , gene , genotype
progressed to AD and 16.54% died. Of the baseline AD group, 49.29% FTR and 35.55% died. Survival analyses indicated clinical groups were equivalent in rate of attrition due to death or FTR, and in rates of mortality with FTR controlled. With mortality and FTR controlled, rate of progression to AD was greater in the MCI group than the rate of progression to MCI or AD in the CN group (p<0.01). Conclusions:The AIBL study has successfully followed over 50% of its initial cohort across 6 years. While group membership at baseline does not predict death or FTR, rates of disease progression are higher in the MCI than CN group. The AIBL study remains as a unique cohort that still contains sufficient sample size for investigation of risk factors for AD.