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P2‐260: Diabetes is associated with worse executive function in both eastern and western populations: Shanghai aging study and mayo clinic study of aging
Author(s) -
Zhao Qianhua
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.801
Subject(s) - medicine , cognition , gerontology , diabetes mellitus , effects of sleep deprivation on cognitive performance , population , demography , cognitive test , psychiatry , endocrinology , environmental health , sociology
Background: It remains unknown whether the association between diabetes mellitus (DM) and cognitive function differs in Eastern and Western populations. This study aimed to elucidate whether DM is associated with worse cognitive performance in both populations. Methods:The Shanghai Aging Study (SAS) and the Mayo Clinic Study of Aging (MCSA) are two population-based studies with similar design and methodology in Shanghai, China and Rochester, MNUSA. Non-demented participants underwent cognitive testing, and DMwas assessed from the medical record. Separate analyses were performed in SAS andMCSA regarding the association between DM and cognitive performance. Results:A total of 3348 Chinese participants in the SAS and 3734 American subjects in the MCSA were included. Compared with MCSA subjects, SAS participants were younger, less educated, and had lower frequency of vascular disease, APOE ε4 carriers and obesity. Participants with DM (compared to non-DM participants) performed significantly worse on all the cognitive domains in both the SAS andMCSA. After adjustment for age, sex and education, and vascular covariates, DM was associated with worse performance in executive function (b1⁄4 -0.15, p1⁄4 0.001 for SAS, and b1⁄4 -0.10, p1⁄4 0.008 for MCSA) in the total sample and in the cognitively normal sub-sample. Furthermore, DM was associated with poor performance in visuospatial skills, language, and memory in the SAS, but not in the MCSA. Conclusions:Diabetes is associated with cognitive dysfunction, in particular exerts a negative impact on executive function regardless of race, age and prevalence of vascular risk factors.