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P2‐179: In‐vivo staging of preclinical amyloid deposition
Author(s) -
Grothe Michel J.,
Barthel Henryk,
Sabri Osama,
Teipel Stefan J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.718
Subject(s) - pathology , amyloid (mycology) , alzheimer's disease , cortex (anatomy) , medicine , neuroscience , psychology , disease
for clinical and cognitive correlation. Methods:Cognitive and postmortem neuropathological data were obtained from 70 brains donated to the Tissue Bank of the CIEN Foundation according to recently developed staging schemes for Alzheimer’s type and vascular pathology. Subjects belonged to a cohort of institutionalized patients with moderate or severe dementia and a mean follow-up period of 7 years. Results:Using combined staging, Alzheimer’s and vascular changes were found in 100% of cases, Lewy type pathology in 11.9%, argyrophilic grains in 3.5 % and hippocampal sclerosis in 9.8%. After classifying all cases into 3 groups [Alzheimer’s predominant (64.1%), vascular predominant (6.3%) and mixed pathology (29.6%)], significant differences were observed in SMMSE and verbal fluency between the vascular predominant and the other groups of patients. Conclusions:The combination of two new scales measuring cerebral vascular and Alzheimer’s type pathology allowed a classification of patients into 3 groups according to the predominant pathology (Alzheimer, vascular and mixed pathology) and revealed differences between groups in premortem cognitive features. Although neuropathological findings are heterogeneous in advanced dementia, staging of Alzheimer’s and vascular pathology yields homogeneous clinicopathological groups.