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P2‐156: Tau positron emission tomography images with a novel tracer, 18F‐THK5351, in a patient with progressive supranuclear palsy
Author(s) -
Ishiki Aiko,
Harada Ryuichi,
Tomita Naoki,
Okamura Nobuyuki,
Furukawa Katsutoshi,
Kudo Yukitsuka,
Arai Hiroyuki
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.695
Subject(s) - progressive supranuclear palsy , medicine , positron emission tomography , nuclear medicine , atrophy , magnetic resonance imaging , pathology , radiology
(r1⁄4-0.46, p<0.05) between the number of detected crossing fibers and age (Fig. 1). To verify our measurements we compared the number of crossing fibers in areas with different tract morphologies: the corona radiata (CR) and the genu of the corpus callosum. As expected, more crossing fibers were detected in the CR, a region with fiber orientation heterogeneity, than in the more homogeneous genu (Table 1). Figure 2 shows the fiber complexity at the level of the superior CR calculated with both DKI and DTI. Since many fibers cross the superior longitudinal fasciculus here a large part remains undetected by DTI. Conclusions: Advanced diffusion MRI techniques like DKI enable detection of fibers in heterogeneous regions with crossing fibers. The number of fiber crossings detected with diffusion MRI decreases with age. This may be relevant for the interpretation of tractography in older subjects.