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P2‐145: Retinal imaging in early‐onset Alzheimer's disease
Author(s) -
Crutch Sebastian J.,
Shakespeare Timothy J.,
Csincsik Lajos,
Peto Tunde,
Lengyel Imre
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.683
Subject(s) - retinal , retina , medicine , drusen , retinal pigment epithelium , ophthalmology , neuroscience , posterior cortical atrophy , optical coherence tomography , neuroimaging , atrophy , dementia , pathology , disease , psychology
(Beta1⁄4-0.296, P1⁄40.142). WCTh positively correlated with WRD in PiB(+) ADCI (Beta1⁄40.387, P1⁄40.002), PiB(-) (Beta1⁄40.779, P<0.001) and PiB (+) SVCI (Beta1⁄40.880, P<0.001). However, their correlation is weaker in PiB(+) ADCI than in PiB (-) (P value 1⁄4 0.009) and PiB(+) SVCI (P value 1⁄4 0.016). Furthermore, there were interactive effects of WAD & WRD on WCTh in PiB(+) SVCI group. sCCA showed that in PiB (+) ADCI, cortical thinning pattern related to WAD were quite different from that related to WRD while two cortical thinning patterns were quite similar in PiB(+) SVCI. Conclusions: Our findings suggested that in PiB(+) ADCI, axonal degeneration rather than myelin break down contributed to cortical thinning while in SVCI, axonal degeneration and myelin breakdown correlated each other, and independently for PiB(-) SVCI or synergistically for PiB(+) SVCI affected cortical thickness.