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P2‐138: Early frame of PiB and FDG in autosomal dominant Alzheimer's disease: Similarity, discrepancy, and clinical implication
Author(s) -
Joseph-Mathurin Nelly,
Su Yi,
Vlassenko Andrei,
Jasielec Mateusz S.,
Blazey Tyler,
Friedrichsen Karl A.,
Owen Christopher J.,
Hornbeck Russ C.,
Stevenson Trish A.,
Cash Lisa,
Xiong Chengjie,
Ringman John M.,
Brickman Adam M.,
Koeppe Robert A.,
Ances Beau,
Raichle Marcus E.,
Morris John C.,
Bateman Randall,
Benzinger Tammie L.S.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.676
Subject(s) - precuneus , pittsburgh compound b , fluorodeoxyglucose , dementia , standardized uptake value , medicine , cognitive decline , positron emission tomography , neuroimaging , pathology , voxel , alzheimer's disease , nuclear medicine , disease , neuroscience , psychology , cognition , radiology
Therefore, the aim of the present study was to compare atrophy versus hypometabolism discrepancies in SD to that observed in AD in order to highlight similarities and differences in the pathological processes between both diseases. Methods:Sixteen patients with SD, 24 patients with AD and 39 healthy controls matched for age, sex and years of education underwent both structural MRI and 18F-fluorodeoxyglucose PET scans. Images were spatially normalized using dartel in SPM. Age-adjusted Z-score maps were then computed for each patient and each imaging modality using the healthy controls group as a reference. Direct between-modality voxel-wise comparisons were then performed within each patient group. Results:Between-modality analyses highlighted more atrophy than hypometabolism in the medial temporal lobe in both SD and AD (FWE p<.05). By contrast, more hypometabolism than atrophy was found in extended medial and lateral parietal regions, temporo-parietal and frontal areas in AD, and in much more restricted brain regions in SD, i.e. mainly in the prefrontal regions when using a more liberal threshold (p<.001 uncorrected). Conclusions:Interestingly, both neurodegenerative disorders were found to be characterized by stronger atrophy than hypometabolism in the medial temporal lobe. However, unlike in AD, the pattern of hypometabolism only slightly differed from the pattern of atrophy in SD. This likely reflects distinct neuropathological processes in both diseases with much less distant effect of neuronal damage in the hippocampal formation in SD. Yet, the excessive prefrontal hypometabolism in SD might as well reflect diaschisis, or the higher sensitivity of 18F-fluorodeoxyglucose PET than structural MRI to detect the underlying neuropathology. Altogether, these findings suggest that the pathological mechanisms affecting the brain might be more homogeneous in SD than in AD.