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P2‐135: CSF aß42 is related to cortical metabolism (FDG‐PET) in non‐demented parkinson's disease patients
Author(s) -
Selnes Per,
Stav Ane Lovli,
Auning Eirik,
Johansen Krisztina,
Bjornerud Atle,
Aarsland Dag,
Fladby Tormod
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.673
Subject(s) - dementia , medicine , parkinson's disease , pathological , biomarker , disease , magnetic resonance imaging , population , pathology , lumbar puncture , neuroimaging , psychology , oncology , gastroenterology , cerebrospinal fluid , psychiatry , radiology , biochemistry , chemistry , environmental health
Males, n (%) 81 (52.9) 24 (47.1) 15 (71.4) 89 (46.4) 5.6 0.134 Age, y 74.4 (6.2) 72.9 (6.9) 70.6 (6.3) 71.2(6.5)* 78.3 <0.0005 APOE4 carriers, n (%) 80 (52.6) 21 (41.2) 5 (23.8) 34 (17.7) 48.6 <0.0005 MMSE 28.5 (1.5) 28.7 (1.5) 28.9 (1.1) 28.9(1.4) 2.06 0.105 CDRSB 0.74 (0.98) 0.41 (0.61) 0.14 (0.28)* 0.42 (0.69)* 6.69 <0.0005 ADAS-Cog/13 12.1 (5.5) 9.3 (4.6)* 9.0 (4.8)* 9.5 (5)* 8.56 <0.0005 Memory composite 0.58 (0.50) 0.74 (0.63) 0.98 (0.40)* 0.88 (0.56)* 9.46 <0.0005 Executive composite 0.43 (0.77) 0.62 (0.74) 1.11(0.77)* 0.87 (0.79)* 10.71 <0.0005 Florbetapir SUVr 1.35 (0.17) 1.03 (0.05)* 1.17 (0.09) 1.01 (0.05)* 300.2 <0.0005 CSF Ab42, pg/mL 140 (24) 162 (28)* 228 (24)* 236 (26)* 446.5 <0.0005 t-tau, pg/mL 80 (52) 64 (45) 66 (30) 56 (26)* 10.41 <0.0005 p-tau, pg/mL 48 (23) 30 (16)* 30 (17)* 29 (13)* 36.64 <0.0005 FDG SUVr 6.4 (0.56) 6.44 (0.59) 6.78 (0.55)* 6.62 (0.51)* 6.57 <0.0005 Hippocampal volume z-score -0.47(1.14) -0.23 (1.2) -0.25 (1.36) -0.2 (1.18) 1.35 0.257