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P2‐133: Associations of automated voxel‐based amyloid PET quantitation with regional SUVR, CSF, memory, and in combination with APOE genotype for early Alzheimer's disease detection
Author(s) -
Mikhno Arthur,
Redei Janos,
Mann John,
Parsey Ramin
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.671
Subject(s) - voxel , apolipoprotein e , logistic regression , medicine , correlation , nuclear medicine , disease , mathematics , radiology , geometry
HLD history, amyloid positivity (positive is SUVR>1.1), and the interaction of these variables. mH were analyzed by number of regions showing mH (0, 1, 2, 3, 4, 5+) and by presence/absence of mH. Linear regression and chi-square models were used to assess the relationship of HLD history and amyloid positivity to mH, covaried for age. Results: Both amyloid positivity and HLD history were independently associated with presence/absence and number of regions showing mH (all p<0.05). Participants who were both positive for HLD history and amyloid showed the highest rate of mH positivity (39.2%), relative to those positive for only HLD history (22.5%), only amyloid positivity (28.5%), and those showing neither risk factor (19.3%). These effects were independent of baseline diagnostic group, gender, and APOE ε4 genotype. Conclusions: HLD and amyloid deposition are independent risk factors for mH and show an additive effect such that older adults who are both amyloid positive and have a history of HLD have the highest prevalence and number of mH. Future studies of the clinical implications and underlying mechanisms of these effects are warranted. References: [1] Kantarci et al. (2013) Alz & Dem, 9(5 Supp): S116-23. [2] Landau et al. (2013) J Nucl Med, 54(1): 70-77.