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P2‐126: Relationship of brain β‐amyloid to gait speed
Author(s) -
Campo Natalia,
Weiner Michael W.,
Adel Djilali,
Delrieu Julien,
Hoogendijk Emiel O.,
Rolland Yves,
Cesari Matteo,
Payoux Pierre,
Andrieu Sandrine,
Vellas Bruno
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.664
Subject(s) - gait , preferred walking speed , bonferroni correction , physical medicine and rehabilitation , medicine , dementia , psychology , statistics , mathematics , disease
mutation. Methods: Twelve GSS F198S mutation carriers and ten NCs were imaged using [F]FDG PET with standard techniques. A static 30-60 minute image was created and normalized to a pons reference region to create an SUVR image for each participant. These SUVR images were then assessed on a voxel-wise basis for the effect of clinical diagnosis and mutation carrier status. Voxel-based analyses were covaried for age and gender. Findings were displayed at a voxel-wise threshold of p<0.01 (uncorrected) and minimum cluster size (k) 1⁄4 50 voxels. SPM8 was used for all pre-processing and voxel-wise statistical analyses. Results: At the time of the scan, seven GSS F198S mutation carriers were symptomatic (SC), showing signs of motor and cognitive impairment or dementia, and five GSS F198S mutation carriers were asymptomatic (AC). All NCs showed no cognitive impairment. SCs showed lower glucose metabolism in the left striatum compared to ACs and NCs, and bilaterally in the cerebellum compared to NCs (Fig. 1A-C). ACs showed hypometabolism in the right cerebellum compared to NCs (Fig. 1D).Conclusions:These findings suggest that hypometabolism in the cerebellar and striatal regions may partially underlie motor and cognitive dysfunction in GSS F198S patients.