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P2‐111: Effect of psychotropic drugs on development of diabetes mellitus in patients with Alzheimer's disease
Author(s) -
Chang Ki Jung,
Son Sang Joon,
Kim Dongsoo,
Lee Kang Soo,
Roh Hyung Woong,
Hong Chang Hyung
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.649
Subject(s) - medicine , antipsychotic , hazard ratio , dementia , diabetes mellitus , psychotropic drug , disease , medical prescription , psychiatry , proportional hazards model , incidence (geometry) , confidence interval , schizophrenia (object oriented programming) , drug , pharmacology , endocrinology , physics , optics
visuospatial cognitive disturbances. Methods: MMSE, MOCA-J, FAB and VPTA. Brain MRI, Tc ECD-SPECT, C PiB-PET, I-MIBG myocardial scitigraphy and FDG-PETwere performed. We analyzed Ab1-42 and ptau-181 of CSF, Apolipoprotein E genotype. Results:PCA and DLB showed brain atrophy and hypoperfusion/hypometabolism in the occipito-parietal cortical region. C PiB-PET showed positive findings in EOAD (9/10), DLB (3/9) and PCA (6/6). They showed common CSF results of high ptau181/low Ab1-42, bearing ApoE gene allele ε4. Conclusions: AD-CSF markers and PiB-PET in PCA and a part of DLB have a common pathological mechanism of AD.
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