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P2‐100: Early‐onset versus late‐onset Alzheimer's disease in tunisia
Author(s) -
Sellami Leila,
Ben Djebara Mouna,
Belhouane Ines,
Kacem Imen,
Sidhom Youssef,
Hizem Yosr,
Gargouri Amina,
Gouider Riadh
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.637
Subject(s) - early onset alzheimer's disease , dementia , medicine , disease , pediatrics , age of onset , family history , memory clinic , mendelian inheritance , genetics , biology , gene
to unknown time of symptom onset. The head MRI demonstrated acute infarction at the left posterior insular cortex. MRA of the head and neck showed only hypoplastic A1 segment of the right anterior cerebral artery and 50 % stenosis of the right internal carotid artery which were not contributory to the acute infarction. 48 hours later, facial droop, disarticulation and word-finding difficulty completely improved. However, multiple domains of cognitive impairment were detected. He scored 20/30 on the Montreal Cognitive Assessment. He had significant impairment in delayed recall, letter & animal fluency and repetition tasks. The memory impairment characterized as retrieval deficit which improved with word cues. Naming was intact either in the MoCA or shortened version of Boston Naming Test. Conclusions: Isolated left posterior insular infarction is extremely rare. This case demonstrates the role of this area in multiple cognitive domains including language-related and verbal memory function. Moreover, this is the first report of the verbal fluency deficit associated with isolated left posterior insular lesion. This area is a convergent structure connecting with multiple brain regions, thus the deficits caused by the left posterior insular lesion is more likely to be a consequence of diaschisis rather than the damage of a specialized or isolated center.