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P2‐090: Neuropsychiatric sub‐syndromes over time: A three‐year longitudinal study
Author(s) -
Connors Michael H.,
Seeher Katrin M.,
Crawford John D.,
Woodward Michael,
Ames David,
Brodaty Henry
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.627
Subject(s) - exploratory factor analysis , confirmatory factor analysis , dementia , longitudinal study , psychology , clinical psychology , factor analysis , medicine , psychometrics , psychiatry , disease , structural equation modeling , statistics , pathology , mathematics
patients with different subtypes of dementia. Some of the NPS are associated with genetic biomarkers. The Neuropsychiatric Inventory is the instrument most widely used to explore these symptoms. Methods: 30 patients with AD were included in the study, protein Ta us haplotype was determined focusing on the H1/H2 insertion/deletion polymorphism and subsequently a correlation with NPS was made. c-test was used to compare the allele frequency of each variant with that expected for a population in Hardy-Weinberg equilibrium. Results: The mean age was 64.1 years old (SD614), 63.3%were women, the mean years of education were 8.3 (SD 65.1). In the haplotypes analysis we found only two allelic forms: homozygous H1/H1 (n1⁄421) and heterozygous H1/H2 (n1⁄49) and we did not found homozygous form for H2/H2. Our results shown that the risk by prevalence ratio (PR) for euphoria was 47% (CI 1⁄4 1.14-1.90) higher for H1 / H1 haplotype than for H1/H2, while the risk for disinhibition was 69% (CI1⁄4 1.19-2.39) higher for H1/H1 haplotype too. Other NPS did not show statistical significant PR. Conclusions: These results showed an increased risk for presenting euphoria and disinhibition associated to haplotype H1/H1, and since the prevalence of H1 haplotype has been found higher in other forms of dementia such as FTD-b, it can be hypothesized that the homozygous form H1/H1 may be involved in the clinical presentation across the spectrum of dementias. Further studies are needed to clarify the role of H1 haplotype in dementia phenotypes and studies regarding the prevalence of the haplotypes in general population are needed.