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P2‐077: Identification of potential modifiers of Alzheimer's disease pathology by quantitative mass spectrometry and drosophila genetics
Author(s) -
Minjarez Benito D.,
Valero Maria Luz,
Calderon-Gonzalez Karla Grisel,
Herrera-Aguirre Maria Esther,
Labra-Barrios Maria Luisa,
Sanchez del Pino Manuel M.,
Rincon-Limas Diego E.,
Luna-Arias Juan Pedro
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.614
Subject(s) - biology , neurodegeneration , tau protein , drosophila (subgenus) , disease , alzheimer's disease , microbiology and biotechnology , pathology , genetics , gene , medicine
Forty-two cognitively normal controls (mean age 71.264.50;73% female) were also included. Amnestic-MCI participants walked slower than na-MCI (98.5 vs 112.2 cm/sec, p<0.03) in all test conditions. Adjusted multivariable linear regression showed aMCI was associated with slower gait and higher variability (p<.001) under dual-task tests. MCI participants were further categorized according to median NAA/Cr and Cho/Cr ratios. Participants with low NAA/Cr (n1⁄435) had higher (worse) stride time variability while dual-tasking than those with high NAA/Cr (p1⁄4 .006). Those with high Cho/Cr had slower (worse) gait velocity while single (p1⁄4.015) and dual-tasking (p1⁄4.001). Low NAA/Cr was associated with increased stride time variability while dual-tasking (p1⁄4 0.03). High Cho/Cr was associated with slower gait velocity while single( p1⁄4.009) and dual-tasking (p1⁄4.02). Cortical volume correlated significantly with better gait performance in both conditons, and with decreased stride time. Conclusions: Participants with aMCI, specifically with episodic memory impairment, had poor gait performance under dual-task conditions, suggesting that slowness and higher stride time variability while dual-tasking is a distinct motor feature in aMCI. Those aMCI participants with lower gait performance presented abnormal metabolite ratios in the primary motor cortex suggesting a potential neurodegenration mechanism.