P2‐076: High‐sensitivity serum troponin T and future risk of dementia: The AGES‐Reykjavik study

Forty-two cognitively normal controls (mean age 71.264.50;73% female) were also included. Amnestic-MCI participants walked slower than na-MCI (98.5 vs 112.2 cm/sec, p<0.03) in all test conditions. Adjusted multivariable linear regression showed aMCI was associated with slower gait and higher variability (p<.001) under dual-task tests. MCI participants were further categorized according to median NAA/Cr and Cho/Cr ratios. Participants with low NAA/Cr (n1⁄435) had higher (worse) stride time variability while dual-tasking than those with high NAA/Cr (p1⁄4 .006). Those with high Cho/Cr had slower (worse) gait velocity while single (p1⁄4.015) and dual-tasking (p1⁄4.001). Low NAA/Cr was associated with increased stride time variability while dual-tasking (p1⁄4 0.03). High Cho/Cr was associated with slower gait velocity while single( p1⁄4.009) and dual-tasking (p1⁄4.02). Cortical volume correlated significantly with better gait performance in both conditons, and with decreased stride time. Conclusions: Participants with aMCI, specifically with episodic memory impairment, had poor gait performance under dual-task conditions, suggesting that slowness and higher stride time variability while dual-tasking is a distinct motor feature in aMCI. Those aMCI participants with lower gait performance presented abnormal metabolite ratios in the primary motor cortex suggesting a potential neurodegenration mechanism.