Premium
P2‐005: Development and validation of brain MRI templates from a korean normal elderly population
Author(s) -
Lee Hyunna,
Han Ji Won,
Lee Jung Jae,
Lee Eun Young,
Kim Jae Hyoung,
Kim Ki Woong
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.541
Subject(s) - jacobian matrix and determinant , displacement (psychology) , template , orientation (vector space) , nuclear medicine , pattern recognition (psychology) , mathematics , medicine , artificial intelligence , psychology , computer science , geometry , programming language , psychotherapist
scopolamine induction of a rat model of AD has on oxidative stress, as expressed by the Total Antioxidant Status (TAS) from the temporal lobe, the most sensitive brain area to the effects of the oxidative stress status. Results:The cognitive deficits of scopolamine were confirmed in the Y maze task, as expressed through a significant decrease of the spontaneous alternation. Also, our data indicated that the administration of scopolamine has a significant prooxidant effect, which is manifested by a decrease in the TAS of the temporal lobe, as compared to the controls. Moreover, a significant Pearson correlation was observed between the levels of the behavioural tasks and the values of the TAs in the temporal lobe. Conclusions: In this study we have demonstrated the presence of increased oxidative stress in a rat model of Alzheimer’s disease obtained through the administration of scopolamine. Moreover, there is a significant correlation between the behavioral markers in the Y maze and the levels of TAS, as a result of scopolamine administration.