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P1‐224: Clinical and neuropsychological profile of persons with mild cognitive impairment: A study from india
Author(s) -
Bharath Srikala,
Sadanand Shilpa,
Balachandar Rakesh,
Joshi Himanshu,
Kumar Keshav,
Andrews Sugandhi,
Varghese Mathew
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.424
Subject(s) - apathy , dementia , clinical dementia rating , neuropsychology , psychiatry , context (archaeology) , memory clinic , medicine , anxiety , clinical psychology , psychology , verbal fluency test , cognition , outpatient clinic , cognitive impairment , audiology , disease , paleontology , biology
(SCD) according to different neuropsychological criteria. By following them longitudinally, clinical outcomes are compared to evaluate the stability of MCI diagnoses and prediction of progression. Results: The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, result in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient AD patients in SCD group who eventually converted to dementia. The delayed recall of complex figure test (CFT_DR) identified fewer MCI patients than AVLT_DR and misdiagnosed more preclinical AD patients as cognitive normal. Criteria requiring deficits in both tests produced higher conversion rate in MCI group, but resulted in higher misdiagnosis rate simultaneously. The one test (AVLT_DR deficit) criterion had the largest area under the curve. Conclusions: AVLT is superior to CFT in the stability of diagnoses and prediction of progression. In the clinical setting, the “one test” criterion AVLT has similar sensitivity to both-deficits methods, and is optimal in balancing sensitivity and specificity.