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P1‐222: Auditory verbal learning test is superior to rey‐osterrieth complex figure memory for predicting progression from mild cognitive impairment to Alzheimer's disease
Author(s) -
Zhao Qianhua
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.422
Subject(s) - verbal learning , audiology , neuropsychology , psychology , recall , receiver operating characteristic , memory clinic , medical diagnosis , dementia , verbal memory , neuropsychological test , cognition , medicine , cognitive impairment , psychiatry , disease , cognitive psychology , pathology
memory (WM), attention (AT), executive function (EF) and processing speed (PS). Performance was adjusted for age, education and gender based on a large normative dataset. These tests were independent from those used to determine diagnostic category. Results: AD is defined by significant deficits in multiple cognitive domains: consistent with this, all AD patients exhibited deficits in two or more domains. In contrast, 66% of MCI and 19% of SMI patients showed multiple deficits. These differences were statistically significant. Deficits in EM were seen in 90% of AD cases, compared to 78% of MCI cases and 11% of SMI cases. WM was also frequently affected in AD (58% of cases), again significantly more frequently than in MCI and SMI (11% in both groups). There was a significant correlation between global impairment on the Cantab battery (sum of all scores) and MMSE (r1⁄4.52 p<0.001), which was primarily driven by correlations with EM (r1⁄4.5, p<0.001) and AT r1⁄4.31, p1⁄40.003). Conclusions: These results demonstrate that a brief, 20-minute, computerised cognitive test is sensitive to cognitive impairments across the spectrum of SMI, MCI and dementia, with MCI characterised by deficits in episodic memory, whereas dementia presents with multiple impairments across domains, but primarily affecting episodic and working memory. There is a significant correlation between MMSE and Cantab scores.