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P1‐216: Lc caudal cells show the earliest vulnerability to Alzheimer's disease
Author(s) -
Theofilas Panos,
Ehrenberg Alexander J.,
Dunlop Sara,
Alho Ana T.,
Nguy Austin,
Paraizo Leite Renata Elaine,
Rodriguez Roberta Diehl,
Mejia Maria B.,
Suemoto Claudia K.,
Farfel Jose M.,
Lucena Ferretti-Rebustini Renata Eloah,
Polichiso Livia,
Prata Thamiris V.G.,
Nascimento Camila F.,
Seeley William W.,
Nitrini Ricardo,
Pasquallucci Carlos Augusto,
Jacob-Filho Wilson,
Rueb Udo,
Neuhaus John,
Heinsen Helmut,
Grinberg Lea T.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.416
Subject(s) - brainstem , neuroscience , locus ceruleus , pons , tegmentum , human brain , entorhinal cortex , inferior colliculus , pathology , anatomy , locus coeruleus , biology , medicine , nucleus , central nervous system , midbrain , hippocampus , substantia nigra , dopamine , dopaminergic
46.4% had low likelihood AD and only 3.8% had intermediate or high likelihood AD. The frequency of AD pathology increased linearly with age (p<0.01) (Figure 1). Ninety-four subjects (51.9%) were free of NFTs and another 78 (43.1%) only had a Braak Stage I or II. Only 8.9% of the sample had neuritic plaques. In the subgroup 50-54 years old (24.3%) we could not find any subject with moderate or high likelihood for pathologic AD. The youngest person with moderate likelihood for pathologic AD was 61 years old. Microinfacrts and small vessel disease were found in 15.9% and 24.7% of the sample, respectively. Lewy bodies were identified in only 2.7% of the sample. Age was not associated to non-AD neuropathologic indices. Conclusions: In a community based sample of persons 50-64 years old, intermediate or high likelihood neuropathologic AD is rare before the age of 60.