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P1‐209: Cerebral amyloid angiopathy is not associated with late‐life cognitive performance in the honolulu asia aging study
Author(s) -
Edland Steven D.,
Gelber Rebecca,
Zarow Chris,
Uyehara-Lock Jane,
Sonnen Joshua,
Montine Thomas,
Launer Lenore J.,
White Lon R.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.409
Subject(s) - cerebral amyloid angiopathy , autopsy , medicine , lesion , pathology , senile plaques , parenchyma , apolipoprotein e , cognitive decline , alzheimer's disease , population , postmortem studies , disease , dementia , environmental health
the Petersen criteria. Cortical Ab depositions were measured by F-florbetapir positron emission tomography and expressed as standardized uptake value ratio (SUVR) relative to the cerebellar uptake. The posterior cingulate, precuneus, and mean cortex were selected a priori as regions of interest. Ambulatory BP was recorded to measure awake and sleep BP changes. The dipping status of sleep BP (i.e., percent change from awake BP) was calculated individually and dichotomized to the dipper ( 10%) and nondipper (<10%) groups. Dynamic cerebral pressure-flow relation was assessed by simultaneous recordings of beat-by-beat changes in BP and cerebral blood flow velocity using transcranial Doppler. Results: Age was positively correlated with greater Ab depositions in the posterior cingulate (R1⁄40.25), precuneus (R1⁄40.20), and mean cortex (R1⁄40.17). Attenuated reductions in sleep systolic BP were associated with the higher levels of posterior cingulate SUVR (R1⁄40.23) and remained significant after adjusting for age (partial R1⁄40.17) (Figure 1). When comparing the dippers and non-dippers of sleep systolic BP (Figure 2), the latter group exhibited higher SUVR in the posterior cingulate (1.0960.12 vs. 1.2560.17) and a trend towards the higher levels in the precuneus (1.1960.15 vs. 1.3260.23, P1⁄40.050) and mean cortex (1.1860.09 vs. 1.246012, P1⁄40.074). The cerebral pressure-flow gains were diminished in the non-dippers (Figure 3) and inversely correlated with the posterior cingulate SUVR (R1⁄40.12w0.18). Conclusions: Greater Ab burden in the posterior cingulate is associated with attenuated reductions in sleep BP as well as the diminished cerebral pressure-flow gains. The diminished gains represent a blunted response of cerebral blood flow to changes in arterial BP and suggest a potential link between cerebral blood flow regulation and Ab burden in the brain.